Skip to main content
. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: J Immunol. 2011 Jul 15;187(4):1977–1985. doi: 10.4049/jimmunol.1101247

Figure 4. Uveitogenicity of immunodominant epitopes of human S-Ag in HLA Tg mice.

Figure 4

(A) HLA-DR3(0301), (B) HLA-DR4(0402) and (C) HLA-DQ8 transgenic mice were immunized with 150µg of the respective immunodominant human S-Ag peptides identified in Figure 3, peptide M, peptide N or whole S-Ag protein, and were given 0.4µg of PTX i/p. Eyes were evaluated for EAU by histopathological examination 28–30 days post immunization. Each point represents one mouse (average score of both eyes). Disease scores are combined from six independent experiments for peptide N in DR3(0301) strain, two experiments for peptide#32 and #34 for DR4(0402) strain. Peptides that failed to elicit disease were not studied further.