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. 2011 Aug 4;7(8):e1002170. doi: 10.1371/journal.ppat.1002170

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(a) cM-T807 successfully depleted anti-CD8 cells in periphery and resulted in a rebound of viral replication; (b) transient CD4⁺ T cell depletion in periphery and intestine was observed following the rebound of viral replication (c) increased in CD4⁺ T cell activation and proliferation (as assessed by the study of –DR and Ki-67) were observed, that lasted longer than the rebound in viral replication. CD8 depleted animals: BA38 (▴); V492 (▪); P373 (•).