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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biol Psychiatry. 2011 Apr 30;70(5):425–433. doi: 10.1016/j.biopsych.2011.03.017

Figure 5. Kappa opioid receptor (KOR) antagonism in the basolateral (BLA) and central (CeA) nuclei of the amygdala increases open arm exploration in the elevated plus maze (EPM).

Figure 5

Microinfusions of the KOR antagonist JDTic or vehicle were administered 24 hr prior to EPM testing. (A) JDTic in the BLA increased the percentage of time rats spent in the open arms and the number of open arm entries (mean ± S.E.M.; Student’s t tests). JDTic in the CeA (B) or striatum (STR) (C) did not affect the percentage of time rats spent in the open arms or the number of open arm entries. None of the drug treatments affected closed arm entries or maze crosses (not shown). (D) Summary of cannula tip placements in the BLA (black circles; n=7–9/group), CeA (gray triangles; n=10/group), or STR (gray squares; n=7–9/group). *P<0.05, **P<0.01 vs. vehicle. Images in D published in The Rat Brain in Stereotaxic Coordinates, 3rd ed. (93) and reprinted with permission, Copyright Elsevier (1996).