Table 4. Responsiveness - slopes of change (mean ± SD) of the NNIPPS-PPS scores by Strata.
| PSP | Slope test | MSA | Slope test | Strata | |
| Dimensional scores (max) | N = 305 | P-value | N = 337 | P-value | P-value |
| ADL/Mobility (32) | 4.6±4.4 | 0.00001 | 3.1±4.0 | 0.00001 | 0.0001 |
| Axial bradykinesia (24) | 4.0±4.2 | 0.00001 | 3.0±3.4 | 0.00001 | 0.002 |
| Limb bradykinesia(32) | 4.2±5.9 | 0.00001 | 3.1±4.8 | 0.00001 | 0.007 |
| Rigidity (20) | 2.1±4.3 | 0.00001 | 1.4±3.2 | 0.00001 | 0.03 |
| Oculomotor (21) | 2.2±2.7 | 0.00001 | 1.0±2.8 | 0.00001 | 0.00001 |
| Cerebellar (24) | 0.8±3.1 | 0.0001 | 0.9±3.0 | 0.00001 | 0.92 |
| Bulbar/Pseudo-bulbar (24) | 3.2±3.1 | 0.00001 | 2.2±2.6 | 0.00001 | 0.00001 |
| Mental (38) | 2.1±4.5 | 0.00001 | 1.4±3.4 | 0.00001 | 0.05 |
| Orthostatic (12) | −0.1±2.0 | 0.25 | −0.22±2.8 | 0.15 | 0.66 |
| Urinary (10) | 1.0±2.1 | 0.00001 | 0.8±2.1 | 0.00001 | 0.08 |
| Limb dystonia (16) | 0.8±2.0 | 0.00001 | 0.3±1.7 | 0.005 | 0.0006 |
| Axial dystonia (12) | 0.7±1.9 | 0.00001 | 0.2±1.2 | 0.0008 | 0.0001 |
| Pyramidal (4) | 0.2±1.1 | 0.00001 | 0.2±1.0 | 0.001 | 0.61 |
| Myoclonia (12) | 0.02±1.1 | 0.52 | 0.2±1.5 | 0.02 | 0.14 |
| Tremor (28) | 0.1±2.7 | 0.94 | 0.9±3.5 | 0.00001 | 0.001 |
| Total score (309) | 25.8±20.8 | 0.00001 | 18.5±18.8 | 0.00001 | 0.00001 |
| Total score – 2 * (273) | 25.2±20.1 | 0.00001 | 17.8±17.8 | 0.00001 | 0.00001 |
PSP and MSA columns: NNIPPS-PPS dimensional and total scores slopes of change (mean ± SD points per year) by strata; N: number of patients with at least two usable assessments over the three year follow-up. Maximum (most severe) theoretical scores are indicated in the far left column (brackets).
Strata p value column: p value from ANOVA comparing slope of change between strata.
Slope test columns: p value from within-group t test comparing slopes of change within strata (PSP, MSA) to 0 (no change).
*Total score-2: Cerebellar and Orthostatic scores at follow-up visits were found to be highly biased by interference with walking ability (some items becoming impossible to rate when the patient was unable to stand), and/or motor disability (eg, rigidity), their respective scorings were removed from this Total score calculation with minor alteration in the overall PPS slope of change in both groups.