Figure 1. K-means clustering of serum reactivity profiles of 872 sera (columns) against the arrayed 103 allergens (rows).

(A) The serum reactivity profile generated for each cluster (0–2) at k = 3 are visualized. Each column represents an individual serum grouped as asthmatic (blue), non-asthmatic (gray) and undefined diagnosis (dark red). Reactivity values to individual allergens are classified as either positive (scale of red - class score 1–5) and negative (black - class score 0). (B) The distribution of atopic conditions in each cluster was assessed using the Pearson's X ² test.