. Author manuscript; available in PMC: 2011 Aug 4.

Published in final edited form as: Am J Gastroenterol. 2011 Apr 26;106(8):1527–1543. doi: 10.1038/ajg.2011.129

TABLE 4.

Variables affecting change in Z score of total body BMD at 18 mos for ALL, CD and UC participants

R or difference in ΔZTBBMD (18-0) (CI)
	ALL			CD			UC
VARIABLE	N	R/difference	p	N	R/difference	p	N	R/difference	P
ZTBBMD(screening)	48	−0.304	0.04	36	−0.339	0.04
ΔZHt	48	0.48	0.001	36	0.658	0.000
Average ESR	48	−0.458	0.001	36	−0.397	0.02	12	−0.664	0.02
Average CRP	48	−0.387	0.007	36	−0.356	0.03
Average HCT	48	0.355	0.01	36	0.324	0.05
Average PLT	48	−0.382	0.007	36	−0.330	0.05
Average albumin	48	0.42	0.001	36	0.518	0.001
Average Fe	48	0.461	0.001				12	0.709	0.01
Average 25OHD	47	−0.292	0.05
Wt bearing activity ¹	46	0.306	0.04
Hospitalization ²				10/26	−0.53 (−0.95,−0.1)	0.02
Immunomodulators ²	39/47	−0.49 (−0.91, −0.07)	0.02
Surgery ²	5/48	−0.6 (−1.08, −0.11)	0.02	4/36	−0.65(−1.28,−0.03)	0.04
Disease activity ²	IN:16 ³ M:23 M/S:9	−0.71 (−1.23, −0.2) (moderate/severe vs. inactive)	0.003	IN: 9 ³ MI:19 M/S:8	−0.8 (−1.45,−0.16) (moderate/severe vs. inactive)	0.006

R: correlation coefficient, difference in ΔZTBBMD: ΔZTBBMD in comparison group – ΔZTBBMD in reference group, CD: Crohn disease, BMD: bone mineral density, R: correlation coefficient, ΔZTBBMD: change in total body bone mineral density Z-score, CI: 95% confidence intervals, ZTBBMD: total body bone mineral density Z-score, ΔZHt: change in height Z-score, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, HCT: hematocrit, PLT: platelets, Fe: serum iron, 25OHD: serum twenty five hydroxy vitamin D, Wt: weight

hr/wk,

reference group: no hospitalization, no immunomodulators, no surgery, inactive disease status,

I/M/M/S: Inactive/Mild/Moderate and severe