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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: J Am Chem Soc. 2011 Jul 18;133(31):12293–12297. doi: 10.1021/ja2049012

Table 4.

Catalytic Enantioselective [3+2] Cycloadditions of γ-Substituted Allenes with a Phosphorus-Substituted Olefina

graphic file with name nihms312878u5.jpg
entry R ee (%) yield (%)b
1 Me 99 82
2 CH2CH2Ph 97 79
3 graphic file with name nihms312878t5.jpg 97 87
a

All data are the average of two experiments. For the determination of structure, including stereochemistry, see the Supporting Information.

b

Yield of purified product; for each cycloaddition, the ratio of regioisomers and diastereomers is ≥20:1 (determined by 1H NMR analysis of the unpurified reaction mixture).