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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: J Immunol. 2011 Jul 15;187(4):1664–1673. doi: 10.4049/jimmunol.1100755

Figure 6. Intact DNA repair is necessary for imiquimod enhancement of survival of immortalized lymphoblasts after exposure to ionizing or UV irradiation.

Figure 6

EBV immortalized lymphoblasts derived from a healthy individual with normal DNA repair (A,C), or a from a patient with XPA (B,D) were cultured with medium alone, or medium containing the indicated doses of imiquimod and then exposed to 4000RAD ionizing radiation (137Cs source)(A, B) or 35mJ/cm2 of UVB radiation (C,D). After 24 hours, cell survival was measured using an MTT assay (see methods) (data depicted represent mean +/− SD; **p<0.01, highly significant, ANOVA).