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. 2011 Aug 4;6(8):e23005. doi: 10.1371/journal.pone.0023005

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The identical amino acids are labeled with black background. Sequences more than 80% conserved are highlighted with carmine. Sequences more than 50% conserved are highlighted with cyan. Dots represent the missing amino acids. The bHLH domain, proline-rich and serine-rich regions are defined with bi-directional arrowheads. The bHLH domain was defined by comparison of the ATOH8 sequence (UniProtKB/Swiss-Prot: Q96SQ7, ATOH8_HUMAN) to data from protein database according to the calculation in protein database and protein structure prediction (http://www.compbio.dundee.ac.uk/www-jpred/). The two commonly missing regions in zebrafish, frog and chicken in contrast to mammalian ATOH8 are indicated by blue.