Table 1. Characteristics of the PC346 cell line panel: AR status and hormone response.
PC346C | PC346DCC | PC346Flu1 | PC346Flu2 | |
AR status | wt AR | AR low | AR high | T877A AR |
PSA expression | + + | - | + + | + + |
Growth on steroid-stripped medium | -/+ | + + | + + | + |
Growth with 0.1 nM R1881 | + + | + + | + | + + |
Growth with 1 µM OH-flutamide | -/+ | + + | + + | + + |
The detailed characterization of the PC346 cell lines was the aim of a previous manuscript [8].