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. 2011 Aug 4;6(8):e23009. doi: 10.1371/journal.pone.0023009

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Meskaldji et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A–B. MRI Acquisition: (A) high-resolution T1-weighted image and (B) diffusion images. The T1 is registered on the diffusion images. In every imaged voxel the Orientation Density Function (ODF) is extracted from the diffusion images. C. Whole brain tractography provides an estimate of axonal trajectories across the WM. D. Cortex partitioning into 83 gyral-based parcels using the Freesurfer software (http://surfer.nmr.mgh.harvard.edu). E. Creation of the low-resolution structural connection matrix, representing the fiber density between every pair of the 83 parcels (upper left and lower right blocks: connections in the right, respectively left hemisphere; off-diagonal blocks: inter-hemispheric connections).