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. 2011 Aug 4;6(8):e23211. doi: 10.1371/journal.pone.0023211

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Park et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Previous simulation results are summarized for the effect of two macro-variables, which are mitochondrial distribution and the number of mitochondria, on inter-mitochondrial ROS messenger molecules (mitochondrial distribution is dichotomous variable, so tested for regular and irregular cases). When mitochondrial distribution is regular and the number of mitochondria is relatively high (cardiomyocyte model, yellow spot), inter-mitochondrial ROS propagation is O₂ ⁻ dependent. However, the main messenger ROS molecules are converted to H₂O₂ when mitochondrial distribution is irregular (blue spot) or the cytosolic density of mitochondria becomes relatively low (red spot). (B) Mitochondria-driven ROS propagation pattern of the yellow spot case in (A) (C) RIRR pattern of the green spot case in (A).