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. 2011 Aug 4;6(8):e22764. doi: 10.1371/journal.pone.0022764

Figure 1. Expression of endogenous Liprin-α4 is up regulated after nickel treatment.

Figure 1

(A) Gene Chip data showed expression for members of the liprin alpha family. Expression of Liprin-α4 was up regulated after Ni treatment but other members of the liprin family Liprin-α1/2 and Liprin-α4 were unchanged after nickel. (B) Increasing expression of Liprin-α4 in BEAS-2B cells after 24 h nickel treatment. Liprin-α4 increases in a concentration dependent manner in BEAS-2B cells. (C) Increasing expression of Liprin-α4 in different cell lines. The changes in expression were concentration dependent in A549 and BEP2D cells. (D) The isoforms 201, 202 and 004 were present in BEAS-2B cell. Liprin-α4 variant 004 and 201 was increased after nickel exposure. The isoform 202 was present in BEAS-2B cells but unchanged by nickel. (E) Western analysis shows induced Liprin-α4 protein levels for isoforms 004 (16 and 32 kDa) and 201 (78 kDa) after nickel exposure.