Table 1. Summary of the motor phenotype quantification in the ALS matrix.
Conditions | % Phenotype | % Normal | UAL | N | n | Figure |
Non Injected | 2 | 94.8 | 99.2 | 753 | 32 | n/a |
Mis Fus AMO | 6.9 | 81.6 | N.D. | 87 | 3 | n/a |
Sham Injected | 3.5 | 87.7 | N.D. | 114 | 4 | n/a |
Fus AMO | 56.9 | 25.9 | 75.9 | 437 | 12 | 2Ci + 3Bi + 5Aiv |
Fus AMO + WT FUS | 16.2 | 70.3 | 91.1 | 185 | 6 | 2Cii+3Bii |
Fus AMO + R521H FUS | 61.9 | 21.1 | 74.1 | 147 | 4 | 2Ciii |
Fus AMO + R521C FUS | 34.3 | 47.9 | 80.2 | 169 | 5 | 2Civ |
Fus AMO + S57del FUS | 19.1 | 63.8 | 92 | 94 | 3 | 2Cv |
R521H FUS | 38.4 | 42.6 | 78.3 | 284 | 9 | 2Cvi + 3Di + 5Ai |
R521C FUS | 18.5 | 63.1 | 93.1 | 157 | 5 | 2Cvii |
S57del FUS | 12.2 | 72.5 | 97.8 | 92 | 3 | 2Cviii |
WT FUS | 9.8 | 77.4 | 93.9 | 204 | 6 | 2Cix |
Tardbp AMO | 58.1 | 26.6 | 70.9 | 327 | 8 | 3Ai + 5Av |
Tardbp AMO + WT TARDBP | 19.9 | 58.9 | 86.1 | 151 | 4 | 3Aiii |
WT TARDBP | 18 | 61 | 89.1 | 128 | 3 | n/a |
Tardbp AMO + WT FUS | 32.6 | 49.4 | 83.4 | 172 | 5 | 3Aii |
Fus AMO + WT TARDBP | 58.1 | 27.7 | 77.1 | 148 | 5 | 3Biii |
Fus + Tardbp AMOs | 59 | 20.9 | 69.3 | 139 | 4 | 5Avi |
G348C TARDBP | 54.3 | 23.5 | 75.6 | 221 | 6 | 3Ci + 5Aii |
G348C TARDBP + R521H FUS | 47.1 | 25 | 75.3 | 104 | 3 | 5Aiii |
R521H FUS + WT TARDBP | 30.8 | 40.7 | 78.1 | 91 | 3 | 3Diii |
R521H FUS + WT FUS | 35.6 | 41.4 | 78.9 | 87 | 3 | 3Dii |
G348C TARDBP + WT TARDBP | 44 | 21.1 | 70.5 | 109 | 3 | 3Ciii |
G348C TARDBP + WT FUS | 48.9 | 22.9 | 73 | 96 | 3 | 3Cii |
WT SOD1 | 8 | 68.2 | N.D. | 88 | 3 | n/a |
Tardbp AMO + WT SOD1 | 58.5 | 25.5 | 71.8 | 94 | 3 | 3Aiv |
Fus AMO + WT SOD1 | 57.1 | 29.5 | 76.2 | 112 | 3 | 3Biv |
G348C TARDBP + WT SOD1 | 53.8 | 21.5 | 75.3 | 93 | 3 | 3Civ |
R521H FUS + WT SOD1 | 38.8 | 41.2 | 75.9 | 85 | 3 | 3Div |
Sod1 AMO | 12.3 | 67.9 | N.D. | 81 | 3 | n/a |
Sod1 + Tardbp AMOs | 55.8 | 25.2 | 71.9 | 104 | 3 | 3Av |
Sod1 + Fus AMOs | 58.7 | 25 | 75.4 | 92 | 2 | 3Bv |
Sod1 AMO + G348C TARDBP | 58.4 | 22.5 | 75.6 | 89 | 3 | 3Cv |
Sod1 AMO + R521H FUS | 39.2 | 40.2 | 78.2 | 102 | 3 | 3Dv |
G93A SOD1 | 33.1 | 44.4 | 81.4 | 223 | 5 | 5Bi |
G93A SOD1 + WT FUS | 34.6 | 42.1 | 76.4 | 107 | 3 | 5Bii |
G93A SOD1 + WT TARDBP | 33 | 44 | 80.2 | 91 | 3 | 5Biii |
G93A SOD1 + R521H FUS | 58.8 | 17 | 67.9 | 153 | 5 | 5Biv |
G93A SOD1 + G348C TARDBP | 57.2 | 19.2 | 68.4 | 187 | 5 | 5Bv |
Summary of the motor phenotype quantifications (TEER; % and UAL; µm) for all the conditions described in this study. After each experiment (n), embryos (N) were separated into four groups and the percentages were calculated for dead and developmentally deficient (2–20%, data not shown) as well as normally developed fish with delayed (phenotype) or normal swimming following the TEER. Also the length (µm) of the axonal projections (UAL) from motor neurons was assessed for each group. The last row indicates the Figure where these data are presented.