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. 2011 Aug 4;7(8):e1002200. doi: 10.1371/journal.pgen.1002200

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Brabin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Model to illustrate the relationship between ELT-1, BRO-1 and EFF-1 in the maintenance of the seam stem cell-like fate. Direct transcriptional activation of bro-1 by ELT-1 promotes proliferation, while repression of eff-1 by ELT-1 (either directly or indirectly, for example through elt-5/6) represses fusion mediated by EFF-1, thereby preventing differentiation.