. Author manuscript; available in PMC: 2011 Aug 4.

Published in final edited form as: Ann Biomed Eng. 2011 May 18;39(8):2213–2222. doi: 10.1007/s10439-011-0325-2

Table 3. Crosstalk protein functional enrichment.

Interesting and statistically significant functional enrichments from the sets of crosstalk proteins. (A) Functions of crosstalk proteins from TSP1-containing proteins, CXC chemokines, and type IV collagens. (B) Functions of crosstalk proteins from TSP1-containing proteins and type IV collagens. (C) Functions of crosstalk proteins from CXC chemokines and type IV collagens.

Annotation	Adj p-value	Type	Genes
(A) TSP1, CXC, and COL4 Crosstalk Protein Enrichment
cell surface	0.0103	component	CD44, SDC1, SDC4
collagen binding	0.0273	function	CD44, MMP9
(B) COL4 and TSP1 Crosstalk Protein Enrichment
vesicle lumen	0.0046	component	APP, FN1, THBS3
peptide cross-linking	0.00109	process	BGN, FN1, DCN
collagen binding	0.00072	function	FN1, GP6, DCN
thrombospondin receptor activity	0.0952	function	CD36
(C) COL4 and CXC Crosstalk Protein Enrichment
locomotion	0.0274	process	CXCL2, CXCR3, IL8, PF4
cytoplasmic vesicle	0.0288	component	LDLR, PF4, SRGN
G-protein receptor binding	0.0967	function	CXCL2, IL8, PF4