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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Addict Biol. 2011 Feb 11;16(3):428–439. doi: 10.1111/j.1369-1600.2010.00282.x

Figure 5.

Figure 5

PSD-95 KO show intact EtOH-potentiating effects of MK-801. (a) WT and KO pre-treated with MK-801 showed a greater ataxic response to EtOH than mice pre-treated with vehicle (VEH) (n = 9–13/genotype/treatment). (b) MK-801 pre-treatment did not alter the hypothermic response to EtOH, regardless of genotype (n = 8–13/genotype/treatment). (c) WT and KO pre-treated with 0.2 mg/kg MK-801 showed a greater sedative/hypnotic response to EtOH than mice pre-treated with vehicle (n = 8–11/genotype). Data are Means ± SEM. #P < 0.05 versus VEH/same genotype, ##P < 0.01 versus VEH/same genotype, **P < 0.01 WT versus KO