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Inhibition of PKA abrogates nuclear accumulation of pCREB-1α,Δ. Nuclear pCREB-1 levels increase in response to forskolin stimulation for 1 h. This response is partly abrogated by pretreatment with H-89 (2.34-fold). pCREB-1 levels are not affected by pretreatment with other kinase inhibitors. Samples treated with inhibitors alone exhibit no significant change in comparison to untreated cells (data not shown).
