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. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: J Parasitol. 2010 Aug;96(4):758–764. doi: 10.1645/GE-2396.1

FIGURE 4.

FIGURE 4

Trypanosoma cruzi-induced inflammation. BALB/c mice were infected with Tulahuén, Brazil, or Sylvio-X10/4 strain parasites. H&E sections from hearts and quadriceps (skeletal muscle source) obtained from representative mice 30 (A), 60 (B), and 90 (C) days PI were examined microscopically and inflammation graded on a scale of 0 – 4. BALB/c mice infected with Sylvio-X10/4 parasites exhibited significant inflammation in heart sections at 30 and 60 days PI, as did Brazil strain infected mice at 60 days PI. BALB/c mice infected with each of the 3 strains of T. cruzi exhibited significantly more inflammation in skeletal muscle during all time points analyzed as compared to uninfected controls. (ND – Not done, * P<0.05, Mann-Whitney U-test as compared to naïve mice)