Table 3.
Bivariate and Multivariable Predictors of Change in SBP in Prevalent Hemodialysis Patients
| Variable | Bivariate Slope Parameter Estimate (mm Hg) | P | Multivariable Slope Parameter Estimate (mm Hg) | P |
|---|---|---|---|---|
| IDWG (/1% increase) | 1.66 ± 0.25 | <0.0001 | 1.08 ± 0.22 | <0.0001 |
| Predialysis SBP (/1 mm Hg increase) | 0.70 ± 0.02 | <0.0001 | 0.70 ± 0.022 | <0.0001 |
| Dry weight (/1 kg increase) | 0.13 ± 0.07 | 0.0005 | −0.08 ± 0.09 | 0.07 |
| Creatinine (/1 mg/dL increase) | 0.45 ± 0.25 | 0.003 | 0.58 ± 0.33 | 0.001 |
| Diabetes as cause ESRD | 4.7 ± 2.9 | 0.002 | 1.51 ± 3.0 | 0.3 |
| Left ventricular hypertrophy | 4.2 ± 2.6 | 0.002 | * | Not significant |
| Hispanic ethnicity | 11.8 ± 8.3 | 0.006 | * | Not significant |
| DM | 2.9 ± 2.6 | 0.03 | * | Not significant |
| Black race (v nonblack) | 3.04 ± 2.7 | 0.03 | −3.60 ± 3.1 | 0.02 |
| Albumin (/1 g/dL increase) | 2.6 ± 2.2 | 0.02 | 2.27 ± 2.2 | 0.05 |
| Age (/1 y increase) | −0.19 ± 0.08 | <0.0001 | −0.13 ± 0.09 | 0.007 |
| Treatment group | 0.74 ± 2.5 | 0.6 | −0.73 ± 2.7 | 0.5 |
| Coronary artery disease | 2.4 ± 2.9 | 0.1 | * | Not significant |
| Interaction terms | ||||
| %IDWG * age | 0.008 | |||
| %IDWG * dry weight | 0.05 | |||
| %IDWG * DM as cause of ESRD | 0.2 | |||
| %IDWG * predialysis SBP | 0.5 | |||
| %IDWG * black race | 0.9 | |||
| %IDWG * serum creatinine | 0.6 |
Note: Values expressed as number ± 95% confidence interval. Nonsignificant predictors of change in SBP in bivariate analyses included sex; duration of dialysis therapy; tobacco use; antihypertensive class (angiotensin-converting enzyme inhibitor, β-blocker, calcium channel blocker); history of bilateral nephrectomy, arrhythmia, chronic obstructive pulmonary disease, congestive heart disease, cerebrovascular disease, hypertension, or peripheral vascular disease; erythropoietin use; or a history of medical noncompliance. Because of missing data, 418 patients and 29,369 dialysis sessions are included in this model.
Abbreviations: %IDWG, percentage of interdialytic weight gain; SBP, systolic blood pressure; DM, diabetes mellitus; ESRD, end-stage renal disease.
Removed from the final multivariate model with P > 0.10. Treatment group, DM as cause of ESRD, and age were forced into the final models.