TABLE 1.

Results From the Voxel-Wise Analyses: Brain Regions Showing Effects of Arousal and Valence

Region	No. of voxels	Coordinates			BA	Significant effects and interactions
		x	y	z
Greater response to HA than LA stimuli in HSSs (p < .001, two-tailed)
Right hippocampus	454	20	−6	−14	34
Right insula		36	20	−16		SS × Arousal*
Left hippocampus	962	−22	−28	−8
Left insula		−34	12	−16		SS × Arousal*
Left posterior medial OFC	33	−4	34	−14	11	SS × Arousal†
Greater response to HA than LA stimuli in LSSs (p < .001, two-tailed)
Anterior medial OFC	18	0	58	−12	11	SS × Arousal*
Left anterior cingulate	28	−10	44	10	32	SS†
Difference between HA and LA response greater for HSSs than for LSSs (p < .001, two-tailed)
Right insula/IFG	24	40	16	10		SS × Arousal*
Greater response to negative than positive HA stimuli in LSSs (p < .005, two-tailed)
Right putamen	41	30	−12	0		SS × Valence*
Greater response to positive than negative HA stimuli in LSSs (p < .001, two-tailed)
Left putamen	49	−22	20	4		SS × Valence × Arousal*

Note. The first two panels present results comparing responses to high-arousal (HA) and low-arousal (LA) stimuli in high sensation seekers (HSSs) and low sensation seekers (LSSs), the third panel presents results comparing differential response to HA and LA stimuli in HSSs and LSSs, and the last two panels present results comparing responses to positive and negative HA stimuli in LSSs. BA = Brodmann’s area; IFG = inferior frontal gyrus; OFC = orbitofrontal cortex; SS = sensation seeking.

^†p = .077.

^*p < .05.