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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Heart Rhythm. 2011 Feb 22;8(7):1024–1032. doi: 10.1016/j.hrthm.2011.02.021

Figure 1. Identification of KCND3-L450F and KCND3-G600R Mutations in BrS.

Figure 1

Mutations in KCND3 are associated with Brugada syndrome. Depicted are A, DHPLC profiles (normal, red trace and abnormal, green trace) and B, DNA sequencing chromatograms. C, Predicted protein topology schematic of Kv4.3 indicating the location of the L450F and G600R mutations. D, Sequence conservation across species for the L450F and G600R mutations.