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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Heart Rhythm. 2011 Feb 22;8(7):1024–1032. doi: 10.1016/j.hrthm.2011.02.021

Figure 3. Kv4.3-L450F and Kv4.3-G600R Plus KChIP2 Increase Ito Current in Heterologous Cells.

Figure 3

A, Representative whole-cell Kv4.3-WT plus KChIP2-WT (left), Kv4.3-L450F plus KChIP2-WT (middle) and Kv4.3-G600R plus KChIP2-WT (right) traces recorded in HEK293 cells elicited by step depolarization of 500 ms duration to +40 mV from a holding potential of −80 mV in 10 mV increments.

B, The current voltage relationship for WT (n= 18), L450F (n=15) and G600R (n=15) Kv4.3 channels co-expressed with KChIP2-WT. All values represent mean±SEM. * p<0.05 vs. Kv4.3-WT plus KChIP2-WT.

C. Bar graph showing peak current density at 40 mV for WT (n= 18), L450F (n=15) and G600R (n=15) Kv4.3 channels co-expressed with KChIP2-WT. * p<0.05 vs. Kv4.3-WT plus KChIP2-WT.