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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Heart Rhythm. 2011 Feb 22;8(7):1024–1032. doi: 10.1016/j.hrthm.2011.02.021

Figure 5. Effects of Kv4.3-L450F and Kv4.3-G600R on the Right Ventricular Epicardial Action Potential.

Figure 5

A, Simulated Ito current traces during step depolarization for 100 ms to 0 mV from a holding potential of −90 mV. Only first 60 ms are shown. Solid line – WT; dotted line – L450F; dashed line – G600R.

B, RV epicardial action potentials simulated using WT, L450F, and G600R mutant Ito incorporated into a modified Luo-Rudy II AP model. BCL = 800 ms (75 bpm). Solid line – WT; dotted line – L450F; dashed line – G600R. Only the 5th AP in the equilibration chain is displayed here, the AP shape does not change in subsequent cycles.