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. Author manuscript; available in PMC: 2011 Aug 4.
Published in final edited form as: Nature. 2010 Dec 15;469(7329):245–249. doi: 10.1038/nature09585

Figure 3. H2AX prevents CtIP-mediated DNA end resection.

Figure 3

(a–b) pMX-DELCJ Southern blot analysis (as described in Fig. 1 a and b) of STI571-treated (a) Lig IV−/−:H2AX−/−:DELCJ and (b) Artemis−/−:H2AX−/−:DELCJ abl pre-B cells expressing either non-targeting (NT) or CtIP-specific (CtIP) shRNAs. (c) Quantification of denaturing Southern blot analysis for open CEs from STI571-treated Artemis−/−:H2AX−/−:DELCJ abl pre-B cells expressing either NT or CtIP-specific shRNAs.