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Direct inhibition of thrombin by designed sulfated benzofuran monomers and dimers. The inhibition of human thrombin was determined spectrophotometrically through a Spectrozyme TH hydrolysis assay at pH 7.4 and 25 °C. Solid lines represent sigmoidal fits to the data to obtain IC50, YM, and YO (equation 1), as described in the experimental section. See text for details.
