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. Author manuscript; available in PMC: 2012 Aug 11.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5403–5413. doi: 10.1021/jm200325s

Scheme 1.

Scheme 1

Synthesis of A-ring, B-ring, and C-ring substituted analogues.a

aReagents and Conditions: (i) HO-R, Cs2CO3, 90°C, 24 hrs; (ii) SnCl2, EtOH, 70°C, 3 hrs; (iii) CH3I, acetone, K2CO3, reflux, 3 hrs; (iv) SOCl2, 100°C, 30 min; (v) CH2Cl2, RT; (vi) NH4OH, CH2Cl2, RT; (vii) H2N-R, ether, RT.