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. Author manuscript; available in PMC: 2012 Aug 11.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5403–5413. doi: 10.1021/jm200325s

Scheme 2.

Scheme 2

Synthesis of linker modified analogues.a

aReagents and Conditions: (viii) 3,5-dichloro-salicylaldehyde, EtOH; (ix) NaCNBH3, EtOH; (x) CH3I, acetone, K2CO3, reflux 3 hrs; (xi) 5a, CH2Cl2, RT.