Skip to main content
. Author manuscript; available in PMC: 2012 Aug 11.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5403–5413. doi: 10.1021/jm200325s

Table 2.

SAR of A-ring substituted analogues

graphic file with name nihms310247u2.jpg
Cmpd A1 A2 A3 PARG IC50 (μM)
6a Cl Cl OH 12 ± 2
6b Cl Cl H NI
6c H H OH ~500
6d Cl H OH 117 ± 60
6e H Cl OH 61 ± 12
6f Cl Cl OMe NI
6g H H COOH 72 ± 7

NI (Non inhibitory): no detectable inhibition of PARG up to 500μM