Table 3.
SAR of linker modified analogues
 | ||
|---|---|---|
| Cmpd | PARG IC50 (μM) | |
| 5a |
|
12 ± 2 |
| 9 |
|
NI |
| 10 |
|
NI |
| 12 |
|
140 ± 20 |
NI (Non inhibitory): no detectable inhibition of PARG up to 500μM
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