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. Author manuscript; available in PMC: 2012 Aug 11.
Published in final edited form as: J Med Chem. 2011 Jul 8;54(15):5403–5413. doi: 10.1021/jm200325s

Table 5.

Cross inhibition with PARP-1

Cmpd PARG IC50 (μM) PARP-1 IC50 (μM)
1e 8 ± 0.6 123 ± 19
1f 22 ± 2 22 ± 6
1g 26 ± 3 78 ± 14
6a 12 ± 2 120 ± 22
6g 72 ± 7 66 ± 6
8b 261 ± 75 ~500
8c ~500 ~500
ADP-HPD* 0.12 >1000
Benzamide# >1000 5.4 ± 0.4
*

See references 30

#

See Reference 38