Figure 5.

Disarray in the supramolecular assembly of ATP synthase in Drosophila mutants with cardiolipin deficiency. (Upper) 3-D models of membrane vesicles from flight-muscle mitochondria of wild-type flies (WT), cardiolipin synthase mutant flies (ΔCLS), and tafazzin mutant flies (ΔTAZ). The lower panel shows corresponding 3-D models, in which neighbors are connected by lines. A particle is considered the neighbor of another particle if their distance from each other is within 27 nm and if there is no other particle in between the two. The models show less connectivity in the supramolecular structure of ATP synthase in the cardiolipin mutants.