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. Author manuscript; available in PMC: 2011 Aug 5.
Published in final edited form as: J Autoimmun. 2010 Jul 16;35(3):176–180. doi: 10.1016/j.jaut.2010.06.004

Fig. 1.

Fig. 1

Analysis of the expression of the CD127 and CD39 antigen on CD8 Tregs from PBC patients and healthy subjects. Panel a: Percentage of CD127 positive cells in in vitro generated CD8 Treg from PBC patients and healthy controls and comparison of the mean percentages of CD8+CD28−CD127+ cells before (t0) and after (t7) CD8 Treg in vitro generation with cells from PBC patients (black bars) and healthy controls (white bars). A statistically significant decrease of CD127 antigen expression was observed on control cells but not on cells from PBC patients (P = 0.05). Panel b: Percentage of CD127 positive cells in ex vivo freshly isolated CD8+CD28− T lymphocytes from PBC patients and healthy controls. Panel c: Percentage of CD39 positive cells in in vitro generated CD8 Treg from PBC patients and healthy controls and comparison of the mean percentages of CD8+CD28−CD39+ cells before (t0) and after (t7) CD8 Treg in vitro generation with cells from PBC patients (black bars) and healthy controls (white bars). A statistically significant difference was observed between the two groups (P = 0.0032). Panel d: Percentage of CD39 positive cells in ex vivo freshly isolated CD8+CD28− T lymphocytes from PBC patients and healthy controls. All the experiments were conducted in duplicate and data are expressed as percentage means ± SD of the two results obtained.