Table 1. Incidence of bacterial infections in children with severe acute malnutrition.
Year | Country | No. of children (% HIV+) | Grade of malnutrition | Bacteraemia (%) | LRTI (%) | UTI (%) | Isolated bacteria | Antibiotic resistance in vitroa |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TMP-SMX | Clavul | Ampi | Genta | CAF | Ceph | Cipro | ||||||||
2006 | United Republic of Tanzania9 | 781 (19) | Severe | 3 | 17 | 8 | NR | |||||||
2006 | Kenya9 | 340 (9) | Severe | 5 | 7 | – | NR | |||||||
2006 | Uganda10 | 450 (36) | Severe | 17 | – | – | Salmonella typhimurium, Staphylococcus aureus, Salmonella enteritidis, Streptococcus pneumoniae | +++ | ++ | ++ | ||||
2006 | Uganda11 | 315 (39) | Severe | 18 | 68 | 26 | NR | |||||||
2006 | Uganda12 | 134 (44) | Severe | 22 | – | – | Salmonella spp, Escherichia coli | +++ | +++ | ++ | ++ | |||
2005 | Kenya13 | 91 (43) | Severe | 29 | – | Coagulase-negative staphylococci | ++ | ++ | ++ | ++ | ||||
2002 | Nigeria14 | 194 (NR) | Severe | – | – | 11.3 | Escherichia coli, Klebsiella spp, Pseudomonas spp | +++ | +++ | + | ++/+++ | |||
2001 | Congo15 | Unclear | Severe | 13.2 | – | – | Enterobacteriaceae | ++ | ++ | ++ | ||||
2001 | Jamaica16 | 150 (NR) | Mod-severe | 10 | – | – | Coagulase-negative staphylococci | + | + | + | ||||
2000 | Malawi17 | 75 (25) | Severe | 9 | – | 17 | Streptococcus pneumoniae, Klebsiella spp, Escherichia coli | |||||||
2000 | Turkey18 | 103 (NR) | All | – | – | 31 | Escherichia coli, Klebsiella spp, Proteus spp | +++ | + | + | ||||
1996 | South Africa19 | 323 (NR) | Severe | 9.6 | – | – | Gram-negative enteric bacilli | |||||||
1995 | South Africa20 | 134 (NR) | Severe | – | – | 26 | Gram-negative enteric bacilli | |||||||
1994 | Gambia21 | 378b (NR) | All | – | 28 | – | Streptococcus pneumoniae, Haemophilus spp | |||||||
1992 | South Africa22 | 134 (NR) | NR | – | – | 26 | NR | |||||||
1992 | United Republic of Tanzania23 | 164 (NR) | Severe | Infections at admission: 92% In-hospital infections: 49% |
Staphylococcus aureus, Escherichia coli, Klebsiella spp, Enterococcus faecalis, Escherichia coli |
Ampi, ampicillin; CAF, chloramphenicol; Ceph, cephalosporin (ceftriaxone; cefotaxime, ceftazidime); Cipro, ciprofloxacin; Clavul, amoxicillin and clavulanic acid; Genta, gentamicin; LRTI, lower respiratory tract infection; NR, not reported; spp, species; TMP-SMX, corimoxazole; UTI, urinary tract infection.
a + > 20%; ++ > 50%; +++ > 75%.
b Children with pneumonia.