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Cumulative dose-response curve on Day 8. Formulas of drug injections, including Mo-NS, Mo-DMSO, Mo-25 Cur andMo-400 Cur, indicate morphine (10 mg kg−1, s.c.) followed by normal saline (100 μL, i.p.), morphine (10 mg kg−1, s.c.) followed by DMSO (100 μL, i.p.), morphine (10 mg kg−1, s.c.) followed by low-dose curcumin (25 mg kg−1, i.p.) and high-dose curcumin (400 mg kg−1, i.p.), respectively, for 7 days. The interval between injections in each group was 15 min.
