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. Author manuscript; available in PMC: 2011 Aug 5.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Mar 24;19(10):2865–2869. doi: 10.1016/j.bmcl.2009.03.080

Table 4.

Human and rat FAAH potency (kinact/Ki values)15 for compounds 15–18 showing SAR of the piperidine linker

hkinact/Ki (M−1 s−1) rkinact/Ki (M−1 s−1)
15 3601 1226
16 5441 991
17-rac 114 48
17-E1 34 <10
17-E2 617 110
18-rac 200 79