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. Author manuscript; available in PMC: 2012 Feb 4.
Published in final edited form as: Nature. 2011 Jul 20;476(7358):101–104. doi: 10.1038/nature10239

Figure 4. DMRT1 regulation of postnatal gene expression.

Figure 4

(a) qRT-PCR analysis of sex-determining genes at P28. Significance of expression changes is indicated (Students t-test). Mutant gonads were SCDmrt1KO(Sf1); SCDmrt1KO(Dhh) mutant gonads and equivalent expression changes. (b) qChIP analysis of DMRT1 DNA binding in P28 testes. Significance of enrichment relative to B2m (Students t-test) is shown. (c) Model for regulation by postnatal sex maintenance by DMRT1. Proposed direct regulation based on ChIP and mRNA expression data is indicated by solid lines; indirect or potential regulation is indicated by dashed lines. (Model adapted from Veitia2).