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Retrosynthesis of arylomycin C16. Arylomycin derivatives were synthesized by modification of previously reported protocols.20,34 Briefly, tripeptide macrocycle precursor was synthesized by solution phase peptide couplings and then cyclized via Suzuki-Miyaura macrocyclization. The various lipopeptide tails were assembled via solution phase peptide couplings and then coupled to the macrocyclic core, or the glycine-homologated macrocycle core.
