Table 2.
Activity (MICs (µg/mL)) of arylomycin derivatives with altered lipopeptide tails against strains of S. epidermidis, S. aureus, E. coli, and P. aeruginosa harboring SPase without (Sensitive) and with (Resistant) the arylomycin-resistance conferring Pro residue.
 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| No. | R | Sensitivea | Resistantb | ||||||
| S. epidermidis | S. aureus | E. coli | P. aeruginosa | S. epidermidis | S. aureus | E. coli | P. aeruginosa | ||
| –c |  |
0.5 | 2 | 0.5 | 8 | 8 | >64 | >64 | >64 |
| 16 |  |
1 | 16 | 4 | >64 | 32 | >64 | >64 | >64 |
| 17 |  |
>64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| 18 |  |
4 | 4 | >64 | >64 | 8 | >64 | >64 | >64 |
| 19 |  |
8 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| 20 |  |
8 | >64 | 8 | 16 | 16 | >64 | >64 | >64 |
| 21 |  |
8 | 8 | >64 | >64 | 8 | >64 | >64 | >64 |
| 22 |  |
4 | 16 | >64 | >64 | 8 | 64 | >64 | >64 |
| 23 |  |
8 | 4 | >64 | >64 | 16 | 16 | >64 | >64 |
a
Sensitive strains include wild type S. epidermidis RP62A, lepB(P29S) S. aureus 8325, lepB(P84L) E. coli MG1655, and lepB(P84L) P. aeruginosa PAO1. See text for details.
b
Resistant strains include spsB(S29P) S. epidermidis RP62A, and wild type S. aureus 8325, E. coli MG1655, and P. aeruginosa PAO1. See text for details.
c
Arylomycin C16, included for reference.