Table 2.
Human linkage and animal QTL studies for platelet traits.
| Phenotype description | Sample description | Human or orthologous human regions (LOD) |
Citation |
|---|---|---|---|
| Animal studies | |||
| PLT (Sysmex XE9000 hematology analyzer) | 1,126 F2 progeny from a CBA/CaH X QSi5 intercross | Orthologous regions not given. PLT (LODs 11.2, 6.8, 3.6, 3.5, 3.4) |
Cheung 2004 (24) |
| PLT, MPV (Advia 120 whole blood analyzer) | 279 F2 progeny each from crosses of NZW/LacJ X SM/J and C57BLKS/J X SM/J | MPV – 12q12-13 (24.2) MPV – 16q13-p21 (2.7) PLT – 9q33-34 (3.5) PLT – 11p15 (3.3) PLT – 2p25 (3.2) |
Peters 2005 (25) |
| PLT, MPV (Coulter) | 582 baboons (410 female, 172 male) in 11 pedigrees | PLT/MCV – 1p34.2-p36.23 (3.1) PLT/Hb – 19p13.12-q13.41 (2.2) PLT/MPV – 10q26.3 (2.0) PLT/RDW – 3p23-p22.3 (1.6) PLT/RDW – 10q26.3 (1.5) MPV/RDW – 20p12.1-q11.22 (2.4) MPV/RDW – 10q23.3 (2.0) MPV/MCV – 9q34.2-q34.3 (1.7) MPV/RBC – 8p21.3-p22 (1.6) |
Bertin 2007 (23) |
| PLT, MPV, PDW (CD1700 whole blood analyzer) | 1,033 F2 progeny of White Durox X Erhualian porcine crosses | Orthologous regions not given. PLT (F-val 12.1, 10.1) PDW (F-val 21.7, 11.1, 9.6) MPV (F-val 10.1) |
Yang 2009 (87) |
| PLT, MPV, PDW, PCT (TEK-II mini automatic hemocyte analyser) | 368 purebred piglet (Landrace, Large White, Songliao Black) | Orthologous regions not given. PLT (LR 17.89, 14.61) PDW (LR 22.24, 19.12) |
Gong 2010 (88) |
| Human studies | |||
| PLT (Coulter) | 745 twin pairs (327 MZ, 418 DZ) | PLT – 19q13.11-q13.32 (2.59) PLT – 10q11.23-q22.1 (2.18) PLT – 5q32-q33.2 (1.97) PLT – 2q24.3-q31.1 (1.42) PLT – 5q23.1 (1.26) PLT – 15q11.2 (1.15) |
Evans 2004 (35) |
| PLT (Bayer automated analyzer) | 6 Asian Indian families (125 with PLT+markers) | PLT – 3q23 (3.26) PLT – 3q26.2 (2.52) |
Garner 2006 (33) |
| Epinephrine, ADP and collagen induced PRP aggregation | Up to 724 individuals in families | ADP – 7q21.12 (2.0) Collagen – Xp11.4 (2.0) |
Yang 2007 (57) |
| Pre- and Post-aspirin responses with or without adjustment of baseline measures: most as above in Bray et al. Table 1, additionally Tx-M (ELISA) | 1,231 European ancestry, 846 African ancestry individuals in families | WB ADP post AA – 5q11.2 (3.6) WB ADP post AA – 5q12.3 (3.6) WB ADP post AA – 5q13.1 (2.2) WB ADP post EA – 5q35.3 (2.2) WB epi post EA – 3p14.2 (2.2) WB epi post EA – 11q23.3 (2.2) WB coll. pre AA – 1q23.3 (2.2) WB coll. post EA – 4p12 (2.2) WB coll. post EA – 4p14 (2.2) WB coll. post EA – 4q12 (2.2) WB coll. post EA – 6q25.3 (2.2) Coll. lag pre AA – 19q13.41 (2.2) |
Mathias 2010 (36) |
MCV = mean corpuscular volume, Hb = hemoglobin, RDW = red cell distribution width, PDW = platelet distribution width, PCT = plateletocrit