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PDX-1 auto-loop mechanism and SREBP-1c suppression in β cells. A, PDX-1 activates the Pdx-1 promoter as a cofactor interacting with USFs on the E-box and recruits other cofactors. B, SREBP-1c directly binds to PDX-1 and inhibits this auto-loop mechanism in three ways as follows: canceling the binding of PDX-1 to USFs, inhibiting PDX-1 binding in the enhancer region (area I), and squelching the recruitment of cofactors.
