TABLE 2.

hERG kinetic properties in shRD and shSig1R K562 cells

Steady-state activation was fitted with the Clampfit software using the following Boltzmann function: G/G_max = 1/(1 + e((V½ − V)/k)). Deactivation kinetics were fitted with the following double-exponential function: f(t) = A₁e^−t/τ_slow + C₁ + A₂e^−t/τ_fast + C₂. NS, not significant.

	V1/2	Slope (k)	Deactivation
shRD K562	−0.5 ± 1.9 mV (n = 15)	9.7 ± 0.7 (n = 15)	τslow = 94.1 ± 17.5 ms (n = 6)
			τfast = 17.8 ± 7.0 ms (n = 6)
shSig1R K562	−2.1 ± 1.6 mV (n = 10)	9.7 ± 1.6 (n = 10)	τslow = 103.0 ± 29.1 ms (n = 7)
			τfast = 10.9 ± 2.2 ms (n = 7)
Mann-Whitney	NS	NS	NS