FIGURE 6.

Schematic diagram showing a possible biological role for α-syn in the lysosome. GCase (TIM barrel motif and C-terminal β-sheet domain colored light blue and pink, respectively) is recruited by α-syn to an intra-lysosomal vesicle with gangliosides shown (lavender), a source of glucocerebroside (boxed). The membrane-bound region of α-syn is modeled as a single helix (blue, residues 1–95), though more dynamic structure is possible (68). The GCase binding residues of α-syn are colored red.