FIGURE 1.

Dhrs3 is a p53-inducible gene. A, mouse embryonic fibroblasts harboring a single p53ER fusion allele and a single p53 null allele (p53 ER/-MEF) cell lines with the indicated Mdm2 genotypes were treated for 12 and 24 h with 4-OHT. Cells were harvested and analyzed by Western blot. B, corresponding microarray Log₂ expression values of p53 ER/-MEF cell lines following 24 h treatment with 4-OHT. C, p53 ER/-MEF cell lines with the indicated Mdm2 genotypes were treated for 24 h with 4-OHT. Cells were harvested and analyzed by Western blot.