FIGURE 2.

Antiviral activities of the chimeric inhibitors against R5-tropic virus. Chimeric inhibitors showed higher anti-HIV potency than the control groups (RANTES variants alone, C37 alone, or 1:1 mixture of the RANTES variants and C37). A and B, cell-cell fusion assay using effector cells expressing ADA viral envelopes. C and D, single-cycle viral infection assay (Ba-L strain pseudoviral particles infecting TZM-bl cells). E and F, replication-competent viral assay (Ba-L strain virus infecting TZM-bl cells). Data shown are typical results of single assays done in triplicate. Error bars represent standard deviations of the data. Refer to Tables 1 and 2 and supplemental Tables S1 and S3 for number of repeats.