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. 2011 Jun 13;286(32):28544–28555. doi: 10.1074/jbc.M111.255646

FIGURE 2.

FIGURE 2.

SMS2 deficiency improves diet-induced obesity and impaired glucose tolerance. A, body weight was measured in male wild type (WT) or SMS2 knock-out (SMS2 KO) mice fed a high fat diet (HFD) or normal diet (ND). n = 15–24 mice per group; *, p < 0.01; #, p < 0.00001 between WT/HFD and SMS2 KO/HFD. B, food intake was determined using both HFD-fed and ND-fed groups of WT and SMS2 KO male mice during 7–9 weeks of age. Data are presented as the mean ± S.D., using 7–8 mice. N.S., not significant. C, fasting blood glucose was determined after an 18-h fast. D, GTT was performed on the mice during the DIO test. E, results of the GTT in D are expressed by the area under the curve (AUC). F, plasma insulin levels in 8-week-old male mice were determined by ELISA as under “Experimental Procedures.” C–F, data are presented as the mean ± S.D. of experiments in 8–12 mice; *, p < 0.05 between WT/HFD and SMS2 KO/HFD.