Figure 2.

A T₁-contrast enhanced brain MRI-scan showing a right frontal GBM tumor, as adapted from Ref. [11]. Perifocal hypointensity is caused by significant edema formation. The hyper-intense, white region (ring-enhancement) reflects an area of extensive blood-brain/tumor barrier leakage. Since this regional neovascular setting provides tumor cells with sufficient nutrition it contains the highly metabolizing, e.g. dividing, tumor cells Therefore, this area corresponds to the outermost concentric shell of highly proliferating neoplastic cells in our model (see Figure 5).