Figure 6.

An illustration of the minimalist proliferation algorithm through a cross-section of the solid tumor [11]. (a) A tumor contains necrotic (black), non-proliferative (yellow or light gray) and proliferative cells (red or dark gray). The average overall tumor radius R_t and the necrotic region radius R_n are shown. (b) Two non-proliferative cells that more than δ_n away from the tumor edge are turned into necrotic and two proliferative cells are selected with probability p_d to check for division. If there are non-tumorous cells within a distance δ_d from the selected proliferative cell, it will divide; otherwise, it will turn into a non-proliferative cell. (c) One of the selected proliferative cell divides and the other turns into a non-proliferative cell.