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. Author manuscript; available in PMC: 2011 Aug 5.
Published in final edited form as: J Med Chem. 2009 Sep 24;52(18):5619–5625. doi: 10.1021/jm900577k

Table 5.

κ opioid receptor potencies and efficacies in the AC assay of Dyn A analogs cyclized by RCM

Compound EC50 (nM) Maximum AC % inhibitiona
1 190 ± 19 90 ± 2
2 27 ± 0.0 104 ± 4
3 0.80 ± 0.34 111 ± 6
4 0.47 ± 0.11 107 ± 4
5 23 ± 11 110 ± 10
6 8.3 ± 3.7 106 ± 6
Dyn A-(1-11)NH2 0.39 ±0.02 100
a

Relative to Dyn A-(1-11)NH2 (100%).