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. 2011 Aug 5;6(8):e22046. doi: 10.1371/journal.pone.0022046

Figure 4. Schematic illustration of gene organizations of different MC receptors from different vertebrates depicting novel intron insertions in MC5R and MC2R from selected ray finned fishes.

Figure 4

There are three intron inserted at positions 41a, 77c and 140c (human MC5R amino acid numbering with suffix a–c for intron phasing) in MC5Rs of four fishes - Takifugu, Tetraodon, stickleback and medaka. There is one intron inserted at position 140c in MC2Rs of same four fishes. The intron at position 140c is found in the middle of highly conserved DRY of both MC5R and MC2R. Takifugu and stickleback has one intron inserted in their MC2R at intron positions 230c (blue arrow) and 236a (green arrow), respectively. These introns are not found in any other MC receptors from zebrafish, lampreys, elephant shark and tetrapods. Transmembrane regions are marked as TM1–7 as predicted by TMHMM2.0 [106].